It is the type of Diabetes mellitus

We all know how diabetes has become a common health concern across all age groups

Another type of diabetes, which we know little about, is the Latent Autoimmune Diabetes. It is the type of Diabetes mellitus. Similar to Type 1 diabetes mellitus (T1DM), LADA occurs when the body’s immune system attacks and destroys its insulin-producing pancreatic cells. This results in the absence of the glucose-lowering hormone, insulin and resultant diabetes. It resembles type 2 diabetes mellitus(T2DM) in that it occurs in older people (>35 yrs.) and shows a slower loss of insulin production as compared to T1DM. It is therefore sometimes referred to as type 1.5 Diabetes Mellitus to highlight the standard features it shares with T1DM, and T2DM.many researchers consider it a subtype of T1DM while others do not acknowledge it as a distinct entity.

We all know how diabetes has become a common health concern across all age groups. Another type of diabetes, which we know little about, is the Latent Autoimmune Diabetes. It is the type of Diabetes mellitus. Similar to Type 1 diabetes mellitus(T1DM), LADA occurs when the body’s immune system attacks and destroys its insulin-producing pancreatic cells. This results in the absence of the glucose-lowering hormone, insulin and resultant diabetes. It resembles type 2 diabetes mellitus(T2DM) in that it occurs in older people (>35 yrs.) and shows a slower loss of insulin production as compared to T1DM. It is therefore sometimes referred to as type 1.5 Diabetes Mellitus to highlight the standard features it shares with T1DM, and T2DM.many researchers consider it a subtype of T1DM while others do not acknowledge it as a distinct entity.

What are the causes?

LADA is a slowly progressing type of diabetes of auto-immune origin. Auto-immune diseases occur when the body’s immune system attacks the body’s organs. In LADA, this organ is the pancreas that slowly loses its insulin-producing cells under attack from the immune system. Since it is a slow process unlike in T1DM, (where the pancreatic damage and insulin deficiency happens rapidly)patients do not require insulin for a few months up to several years.

How is it different from type 1 and type 2 diabetes?

T1DM-The age is a diagnosis of LADA is typically 30-50 yrs, unlike in T1DM, which is diagnosed in childhood or adolescence. The destruction of insulin-producing pancreatic cells is prolonged in LADA, unlike in T1DM, seldom resulting in acute complications. It is also believed that there is a resistance to the effects of insulin in some patients with LADAunlike T1DM and similar to T2DM. Unlike in T1DM, these patients can be managed on diet and exercise and oral medications for a few months or years after diagnosis.

T2DM-LADA patients are usually positive for autoantibodies against the pancreatic insulin-producing cells. In T2DM, there is excessive Insulin production that does not function properly to control blood glucose levels while in LADA insulin levels are decreased. There is frequently a strong family history of diabetes in T2DM, unlike in LADA. On the contrary, there is a strong family history of auto-immune disease in LADA, unlike in T2DM.

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